Codeine is an opiate analgesic, meaning it is a pain reliever derived from the opium poppy plant. Its pain relief properties, as well as its side effects, are less than the related opiates Morphine and Heroin.

Doctors sometimes prescribe pills containing combinations of codeine and over-the-counter (OTC) analgesics, such as Tylenol (acetaminophen) or aspirin, for pain relief after minor surgery, or for broken bones, muscle sprains, migraine headaches, or other pain that is expected to pass relatively quickly. The other most common use of codeine is in cough syrup.



Hydrocodone also known as dihydrocodeinone, belongs to a group of drugs called opioids often referred to as narcotics. It relieves pain by binding to certain receptors in the central nervous system mostly the μ-opioid receptor also known as MOR.

Hydrocodone is a semi-synthetic opioid drug. It is synthesized from codeine, an opioid alkaloid found in poppy. Hydrocodone has the same effect on the body as the better known opioid morphine.  Hydrocodone Opioids are a group of medications most commonly used to relieve moderate to severe pain, but can be used to treat a cough and diarrhea.


Morphine is an opiate-type of medication which is naturally found in some plants and animals. It acts directly on the central nervous system (CNS) to decrease the feeling of pain. It can be used for both acute and chronic pain, such as the one in a myocardial infarction or labor. Morphine can be administered orally, rectally, intravenously, by injection into a muscle, under the skin or into the space around the spinal cord. Its effect peaks at around 20 minutes after the intravenous approach and 60 minutes after the oral administration and it lasts for about three to seven hours. There are also long-acting formulations available on the market.


Tramadol is an opiate-type of medication that acts directly on the central nervous system (CNS). This medication is used in the management of moderate to mild degrees of chronic pain. Usually, it can be administered orally, intravenously, intramuscularly (injecting it into a muscle) and rectally. Its effects peaks at around 20 minutes after the intravenous approach and 60 minutes after the oral administration. Its effects last for about 3 to 6 hours.

This medication is a unique form of an opiode drug when compared to the other opiates. First, Tramadol is a fully synthetic drug. This means that this drug is man-made and it can’t be found in nature. Chemically and structurally, Tramadol resembles a simpler version of codeine. Another thing that makes Tramadol different from the other opiates is its uncommon “dual-action benefit”. When describing this dual-action benefit, first we refer to the way this drug works as an opiate and can easily manage the perception of pain. Second, it alters the neurotransmitter balance in the brain by increasing the levels of norepinephrine and serotonin. Norepinephrine is known for its ability to improve concentration, and the other one, serotonin, manages the sleep and mood functions.